TNF and psoriasis: In FFA4 KO mice, the levels of inflammatory TH23/TH17 axis cytokines (IL-17A, IL-22 and IL-23) and TH1 cytokines (IL-1β, IFN-γ and TNF-α) in the lymph nodes were also increased after psoriasis induction; however, Compound A treatment did not suppress the cytokine levels (Figure 5G–L).