SOST and periodontitis: Establishing a periodontitis model in rats by ligating the first molar with silk thread, researchers found that sclerostin expression in the alveolar bone was higher in rats with periodontitis, and furtherly, increased sclerostin along with decreased osteogenesis in the early stage of periodontitis, then decreased sclerostin followed by more osteoid formation in the later stage [50, 51, 108].