A previous in vitro study of the author found that in lipopolysaccharide-induced inflammatory condition, sclerostin promoted the production of several critical pro-inflammatory cytokines in odontoblasts and inhibited the odontoblastic differentiation of inflamed DPCs, revealing that sclerostin might play a pro-inflammatory role in dental pulp inflammation and impair dentin regeneration [55]. Here, SOST is linked to pulpitis.