Mertoglu et al. [42] found that serum creatinine and BUN have greater diagnostic value compared with other novel markers including myo-inositol oxygenase and cystatin C. Laranja et al. [4] revealed that septic patients with AKI had lower urine output compared with patients with AKI from other cases or chronic kidney disease. This evidence concerns the gene CST3 and acute kidney injury.