In the proinflammatory stage, humoral and cellular immunity can cause a storm of inflammatory factors, leading to the excessive secretion of inflammatory factors (such as interleukin 1 and tumor necrosis factor-α), the activation of complement and coagulation system, the activation of hyaluronic acid and elastase, and eventually the reduction of renal blood flow and the occurrence of AKI and septic shock [6, 47]. The gene discussed is TNF; the disease is septic shock.