In the ICI and TCGA cohorts, we found that expression of LAG3, PDCD1, and PD-L1 (CD274) was significantly elevated in the CXCR3-high patients; however, Vascular Endothelial Growth Factor A (VEGFA), a molecule that promotes tumor angiogenesis, was significantly downregulated in CXCR3-high patients (all p < 0.05; Fig. 3A). This evidence concerns the gene VEGFA and neoplasm.