In addition, the tumor stages of patients in CXCR3-high and low groups are significantly different in ICI cohort (Chi-Square test, p < 0.001,, Additional file 4: Figure S4C), CXCR3-high group seems to have more late-stage patients but there are no differences of tumors stages between CXCR3-high and low groups in TCGA cohort (Chi-Square test, p = 0.5, Additional file 4: Figure S4F). This evidence concerns the gene CXCR3 and neoplasm.