Immunohistochemistry showed that three core proteins associated with the CXCR3 pathway, CXCR3, CXCL9, CXCL10, and were more highly expressed in cancer tissues from the immunotherapy-responder group than in tissues from the immunotherapy non-responder group (n = 1 per group) (Fig. 1F). Here, CXCL9 is linked to cancer.