In the present study, we used the median CXCR3 pathway activation values for the ICI and TCGA cohorts to categorize patients as CXCR3-high or CXCR3-low; however, different cancers may have different levels of CXCR3 activation, which makes this threshold difficult to apply in the clinical setting. The gene discussed is CXCR3; the disease is cancer.