The M2 macrophages increased the release of CXCL8. The hypoxia-activated positive feedback loop CXCL8/CXCR1/2 (C-X-C Motif Chemokine Receptor 1/2)/STAT1/IL-10/NFKB1/CXCL8 could cascade and amplify the interaction between GC and macrophages leading to uncontrolled progressive signaling in GC. The gene discussed is NFKB1; the disease is gastric cancer.