Accordingly, some studies have shown that salirasib alone and its combination with vitamin D (also referred to as calciferol) has anti-fibrotic effects on the liver, as it reduces main fibrotic marker expression such as collagen type I and tissue inhibitor of metalloproteinases-1 (TIMP-1) and, doing so, prevents the development of liver fibrosis [63]. This evidence concerns the gene TIMP1 and Hepatic fibrosis.