The European Academy of Allergology and Clinical Immunology, the Global Allergy and Asthma European Network, the European Dermatology Forum and the World Allergy Organization (EAACI/GA2LEN/ EDF/WAO) 2018 guidelines recommend the use of omalizumab, a monoclonal anti-IgE antibody, for the treatment of unresponsive chronic urticaria [1, 21]. Here, IGHE is linked to asthma.