In contrast to C4-Mye enriched in blood, C6-Mye preferred tumor and paratumor tissue and highly expressed 591 genes (Fig. 5E), including the M2 macrophage marker gene MCR1 (CD206), and highly expressed the M2 macrophage-related protumorigenic genes TGF-β, IL10, VEGFA and MMP9 (Fig. 5F). The gene discussed is MMP9; the disease is neoplasm.