Notably, CCL5–CCR5 and CCL4–CCR5 were predicted to make great contributions to interactions among Tregs(C5–CD4), CD8+ Tex cells (C1–CD8 and C4–CD8) and M2 macrophages(C6-Mye), which were characterized by recruiting and promoting activity of tumor associated immune cells, including TAM, Th17 and Treg cells [51–53]. The gene discussed is CCL4; the disease is neoplasm.