Based on the prognostic value of FABP7 and NDUFAB1 in breast cancer, a prognostic gene signature containing these two LRGs (FABP7 and NDUFAB1) was constructed by LASSO Cox regression analysis (Fig. 4A, B), and the final results were calculated with the formula risk score = (− 0.1013) * FABP7 + (0.3367) * NDUFAB1. The gene discussed is NDUFAB1; the disease is breast carcinoma.