Notably, NSUN2 methylates miRNA-125b in an m6A manner rather than m5C. Vault RNA m5C modification by NSUN2 determines its processing to svRNA, which participates in the regulation of epidermal differentiation [47, 48], while its processing to lncRNA promotes tumorigenesis and aggression in several cancers [49, 50]. The gene discussed is NSUN2; the disease is cancer.