In univariable analysis, patients with EM AML and mutated TP53 compared to EM AML patients with wild-type TP53 had decreased median EFS (0.26 months [95% CI: 0.23–0.97] vs. 7.43 months [95% CI: 5.00–9.40], HR: 4.77 [95% CI: 2.20–10.35], Cox regression p < 0.001, Fig. 4A) and OS (4.80 months [95% CI: 0.99–8.74] vs. 14.10 months [95% CI: 11.21–19.86], HR: 3.16 [95% CI: 1.47–6.82], Cox regression p = 0.003, Fig. 4B). Here, TP53 is linked to acute myeloid leukemia.