GR controls the secretion of glucocorticoids with a regular daily rhythm by time-dependent chromatin binding and target gene transcription to control daily cycles of glucose and triglyceride metabolism [20], moreover, GR plays a pivotal role in activating metabolic genes, including those mediating hyperglycaemia, hyperlipidaemia and obesity [21]. The gene discussed is NR3C1; the disease is obesity due to melanocortin 4 receptor deficiency.