However, for the “fingerprint values” representing the 5FU effect in an individual tumor microenvironment (comparing 5FU treated PDS to untreated PDS), Axin2 and LEF1 were significantly upregulated and downregulated respectively whereas the p53 target gene CDKN1A (p21) was significantly upregulated after 5-FU treatment. Here, TP53 is linked to neoplasm.