NKX2-1 and cystic fibrosis: Mou et al. have firstly reported the generation of multipotent Nkx2.1 + immature lung progenitor cells from mouse embryonic stem cells and CF patient-specific induced pluripotent stem cells (iPSCs) [102], which could mature into Nkx2.1 + /Sox2 + proximal progenitor cells and Nkx2.1 + /Trp63 + airway BSCs in vitro and differentiate into airway epithelium.