CD4 and neoplasm: In IHC staining, representative images of TNFRSF4, CD4, CD8, and FOXP3 were exhibited in Fig. 7D, TNFRSF4, CD4, and CD8 proteins were over-expressed in EC tissues (mainly on tumor immune infiltrating cells) compared with paired adjacent normal tissues or even unpaired normal tissues (Fig. 7E, F).