Initially, evidence was brought by Paterson, D.J [27], who identified TNFRSF4 as a specific marker of T-cell activation and survival when cross-linked with its ligand TNFSF4. Then emerging evidence highlighted that TNFRSF4 was a promising therapeutic target for T cell-mediated anti-tumor immunotherapy [28–30]. The gene discussed is TNFRSF4; the disease is neoplasm.