There were 27 overlapping DEGs between the TCGA cohort and the ICGC cohort (Fig. 2E); 10 DEGs (IL1B, NLRC4, IL6, NLRP3, IL18, TNF, IRF1, AIM2, CASP4, CASP1) were downregulated and 17 DEGs (GSDMC, BAK1, PLCG1, BAX, GSDMD, CASP8, TP63, CYCS, PYCARD, NOD1, CHMP4C, CHMP6, CHMP2A, TIRAP, CHMP4B, CASP3, GPX4) were upregulated in tumor samples. The gene discussed is TNF; the disease is neoplasm.