Moreover, ICAM-1 is also the key protein involved in African trypanosomiasis, one of the major KEGG pathways for downregulated DEPs between group S and group H. Hence, we can conclude that SOD may suppress the OS induced by H2O2 by decreasing ICAM-1 levels to reduce the apoptosis of TMCs. Here, ICAM1 is linked to human African trypanosomiasis.