Moreover, SF3B1 mutation can dysregulate the NF-κB pathway in CLL (Wang et al. 2016), which was persistently activated by somatic gene alterations or viral oncoproteins that have been shown to play a crucial role in NPC tumorigenesis (Tsang et al. 2020; Zeligs et al. 2016). This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.