Regarding the overall somatic alteration frequency in all listed cancers, SLC15A4 showed a generally higher frequency with up to 5.48% in uterine cancer (Online Resource 2a), whereas the maximum alteration frequency of the PTGES gene was only 1.7%, also in uterine cancer (Online Resource 2b) (Cancer Genome Atlas Research et al. 2013; Gao et al. 2013). The gene discussed is SLC15A4; the disease is cancer.