Amongst 263 driver genes, we found 55 genes that were targets of DEHGs, out of which caspase-8 (CASP8), interleukin-18 (IL-18), and transcription factor dimerization partner 2 (TFDP2) were identified as the most common targets of the DEHGs in HNSCC. Here, TFDP2 is linked to head and neck squamous cell carcinoma.