Assessment of the expression of each DEHGs regarding HPV status revealed five DEHGs HOXB13, HOXC5, HOXC6, HOXC9, and HOXD11 which showed a significant difference in expression between HPV-positive and HPV-negative HNSCC tumors, implying their role in cancer-related molecular events in HPV-positive HNSCC. This evidence concerns the gene HOXD11 and head and neck squamous cell carcinoma.