Most proteins of the upregulated or exclusively identified in Opn4WT tumor were associated with positive regulation of G1/S progression (APEX1, GSPT2, PES1, RALA, RALB, RHOB, TBCD, UPF1, USP9X, and RPL17) and negative regulation of G2/M transition (PSMC6). This evidence concerns the gene APEX1 and neoplasm.