In accordance with our previous data, we found that Opn4KO tumor bulk cells display a higher frequency of BMAL1 positive cells with increased protein expression; moreover, in TME we also found that tyrosinase and BMAL1 positive cells (malignant melanocytes) are also enriched in Opn4KO tumors compared to Opn4WT ones. This evidence concerns the gene TYR and neoplasm.