In contrast, Ppard genetic deletion in pancreatic epithelial cells in KC/PdKO mice significantly reversed the effects promoted by GW treatment (Supplementary Fig. 6a-d) and the HFD (Supplementary Fig. 6e, f) in KC mice by decreasing macrophages (Fig. 5l–o) and decreasing MDSCs (Gr1+) (Supplementary Fig. 6c–f). Here, PPARD is linked to keratoconus.