PPARD and keratoconus: However, this PPARδ overexpression in KRASmu pancreatic epithelial cells in KC/Pd mice (Pdx1-Cre; LSL-KrasG12D; CAG-LSL-Ppard) (Fig. 2a), generated by breeding of Panc-Pd mice with KC mice, significantly increased pancreatic neoplastic area compared with that of KC mice, with both groups aged 12-14 weeks or older (Supplementary Fig. 2d–f).