Our screening results for pancreatic tissues indicated that although PPARδ hyperactivation regulated various chemokines, Ccl2 was the only common upregulated chemokine across three settings: 1) the GW diet compared with the control diet for 3 days of treatment in KC/Pd mice; 2) the HFD compared with the control diet in KC/Pd mice, and 3) the HFD compared with the control diet in KC mice (Fig. 6a–c, Supplementary Fig. 7a–l). The gene discussed is CCL2; the disease is keratoconus.