PPARD and keratoconus: PPARδ’s mechanistic role in promoting pancreatic tumorigenesis is not limited to the HFD, as we have demonstrated using GW501516, a specific, synthetic PPARδ ligand33, which caused drastic acceleration of pancreatic tumorigenesis in KC/Pd mice, leading to PDAC development within 9 days and death of these mice within 30 days after GW treatment.