In contrast, sex- and age-matched KC littermates on the same GW treatment for 13 weeks or less (some mice were euthanized earlier because of severe pancreatitis and tumorigenesis) had significantly higher pancreatic weights and larger pancreatic neoplastic lesions than did the KC mice on the control diet (Supplementary Fig. 3f, Fig. 3i–k). This evidence concerns the gene CALCA and pancreatitis.