CALCA and pancreatitis: While the KC mice showed only minimal PanINs after 9 days of GW treatment, all tested KC/Pd mice treated with GW for 3 days had significant acinar cell loss and developed pancreatitis and pancreatic neoplastic lesions, and these tumorigenic effects were intensified in KC/Pd mice on the GW diet for 9 days (Fig. 3c–f).