We first performed Ccl2 RNAscope in situ hybridization to localize Ccl2 mRNA expression in pancreatic cell subpopulations and found that PPARδ hyperactivation by GW treatment for 3 days in KC/Pd mice significantly increased Ccl2 mRNA expression in normal pancreatic epithelial cells compared to the same mice on the control diet (Fig. 6d). This evidence concerns the gene PPARD and keratoconus.