Similar results for Ccl2 mRNA expression were also observed in 1) PDAC cell lines generated from pancreatic tumors of KC or KC/Pd mice that were treated with GW or its solvent control (Fig. 6j); 2) KC PDAC cells transduced with control or mouse PPARδ expressing lentivirus and further treated with GW (Supplementary Fig. 8m); and 3) two mouse iKPC under doxycycline challenge treated with GW or its solvent control (Supplementary Fig. 8n). Here, PPARD is linked to keratoconus.