Among MDSCs, PMN-MDSCs (CD45+CD11b+Ly6ClowLy6G+CD14+)38 were increased at 3 days and further increased at 9 days of GW treatment (Supplementary Fig. 5c, d) while the increase in M-MDSCs plateaued after 3 days of GW treatment (Fig. 5d) in KC/Pd mice. This evidence concerns the gene ITGAM and keratoconus.