Indeed, we found that PPARδ activation by the HFD or GW-upregulated proinflammatory and pro-tumorigenic chemokines (e.g., Ccl2) and increased pancreatic macrophages and MDSC accumulations in pancreata of KC mice, and these events were markedly accelerated by PPARδ hyperactivation in KC/Pd mice. The gene discussed is CALCA; the disease is keratoconus.