ACTA1 and keratoconus: More importantly, the HFD induced more pancreatic neoplastic lesion area, loss of pancreatic acinar cells (amylase positive), more metaplastic ductal cells (cytokeratin-19 [CK19] positive), and more fibrosis (α-smooth muscle actin [α-SMA]+) in KC mice and, to a greater extent, in KC/Pd mice (Fig. 2e, f).