HMGB1 and neoplasm: It is interesting that PDT based on a novel PS, tetrakis[4-(4-fluorobenzyoxy)] phenyl-tetracyanoporphyrazine, induced a mixed types cell death (apoptosis and necroptosis) and triggered a pronounced immunogenic response in vitro (e.g., release of ATP and HMGB1, activation of BMDCs) and demonstrated the protective effect against fibrosarcoma MCA205 cells in the tumor prophylactic vaccination model in immunocompetent C57BL/6 J mice [15].