AR and breast carcinoma: By leveraging the expression of a human MYC transgene (hg19MYC) observed at a single-cell level in murine prostatic tissues, our data demonstrate that MYC overexpression robustly reprograms luminal (Krt8Hi, Krt18Hi) cells toward a repressed AR transcriptional program, a feature contrasting with the supporting role of MYC on the AR transcriptional program in the apocrine breast cancer subtype44.