One example pathway of interest enriched within proteins increased with higher tumor grade, significant (p < 0.05, one-sided Fisher’s exact test) for four out of ten cancer types—lung adenocarcinoma, ovarian, renal, and uterine—was type II interferon signaling (Fig. 2c), involving JAK–STAT-signaling and antiviral and growth-inhibitory effects. This evidence concerns the gene SOAT1 and cancer.