Consistently, based on the median value of DMDRMR expression in ccRCC patients from TCGA, Gene Set Enrichment Analysis (GSEA) revealed that DMDRMR expression is associated with VEGF-related pathways including positive regulation of VEGF production and VEGF pathway (FDR < 0.25) (Fig. S1E, F), suggesting that DMDRMR might be an important modulator of angiogenesis in ccRCC. The gene discussed is VEGFA; the disease is nonpapillary renal cell carcinoma.