We incubated HUVECs with conditional medium collected from ccRCC cells expressing variable amounts of DMDRMR, miR378a-5p or DAB2IP and performed immunoblot assays, the results showed that the inactive effects of DMDRMR KD on the phosphorylation of VEGFR2 and PLC-γ could be partially reversed by DAB2IP KD and miR-378a-5p inhibitor (Figs. 7E and S8A). The gene discussed is LINC00944; the disease is nonpapillary renal cell carcinoma.