To identify potential target miRNAs of DMDRMR, we performed bioinformatic analysis by TargetScan, miRanda and PicTar databases [14–16] and found 137 miRNAs that have at least a site on DMDRMR (Fig. 3B), among which 3 miRNAs including miR-378a-5p, miR-532-5p and miR-199a-5p were significantly downregulated in TCGA ccRCC tissues versus adjacent tissues and further validated (Fig. S3A–C). This evidence concerns the gene LINC00944 and nonpapillary renal cell carcinoma.