DAB2IP, also known as a tumor suppressor in ccRCC, has been reported to be epigenetically repressed by EZH2-mediated methylation of lysine 27 in histone H3 (H3K27me3), and also be degraded by SMURF1-mediated ubiquitin-proteasome regulation [22–24]. This evidence concerns the gene EZH2 and neoplasm.