Although we did not define how the DMDRMR/miR-378a-5p/DAB2IP axis regulates VEGFA expression, we revealed that DMDRMR/miR-378a-5p axis inhibits the inactivation of DAB2IP-regualted VEGFA/VEGFR2 signaling pathway, which can explain our notion that the DMDRMR/miR-378a-5p axis could serve as an angiogenic activator in ccRCC. Here, VEGFA is linked to nonpapillary renal cell carcinoma.