By further considering well-studied oncogenes, we focused on SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) and Enhancer of zeste homolog 2 (EZH2) that extensively regulate gene expression and thereby promote tumorigenesis in various carcinomas, including renal cancer [19, 20]. The gene discussed is SMURF1; the disease is carcinoma.