The parsimonious multivariable model comprised age, diabetes, COPD, ln(NT-pro-BNP), global longitudinal strain, right ventricular ejection fraction, body surface area-indexed left atrial area, myocardial infarction (infarct late gadolinium enhancement), and myocardial extracellular volume (appendix pp 8–9). The gene discussed is NPPB; the disease is diabetes mellitus.