prognostic index=(0·02524519 × age [in years]) + (0·36274393 × diabetes) + (0·55492737 × COPD) + (0·24307998 × ln[NT-pro-BNP in pg/mL]) + (0·07038957 × global longitudinal strain [in %]) + (0·44487534 × myocardial infarction) + (0·07935639 × myocardial extracellular volume [in %]), after centring. The gene discussed is NPPB; the disease is chronic obstructive pulmonary disease.