The first lncRNAs implicated in thyroid cancer, termed papillary thyroid carcinoma susceptibility candidate 1–3 (PTCSC1, PTCSC2, and PTCSC3), are involved in PTC predisposition and are significantly down-regulated in thyroid tumors, implying roles as tumor suppressors38–40. This evidence concerns the gene PTCSC3 and thyroid gland carcinoma.