RIPK3 and acute myeloid leukemia: However, in HPCs, Tnf-α-Ripk3 signaling stimulates the activation of inflammasomes, which might explain the critical role of Tnf-α-Ripk3-inflammasome signaling in the pathogenesis of RUNX1-ETO- or FLT3-ITD-induced AML in models (Hockendorf et al., 2016; Xin et al., 2016b).