In a previous report, Nakayama et al. reported that SKF96365, a TRPC4 blocker, inhibited spontaneous contraction caused by ICC, and revealed that Ca2+ introduced by TRPC4 contributes to the action of RyR3, which is important for inducing pacemaker current.53, 54. The gene discussed is TRPC4; the disease is intrahepatic cholangiocarcinoma.