Given that miR‐25‐3p has a role in inhibiting PHLPP2 and activating AKT signaling in cancer progression, the study suggests a role of the METTL3‐miR‐25‐3p‐PHLPP2‐AKT axis in promoting cigarette smoking‐induced PDAC tumorigenesis.96 This evidence concerns the gene PHLPP2 and cancer.