Srivastava et al.32found that overexpression of SIRT3 inhibited α‐SMA as well as glycolytic enzymes such as hexokinase, hexokinase in renal ECs in mice with diabetic kidney disease phosphofructokinase activity and lactate levels, thereby inhibiting EndMT and protecting the kidney. Nevertheless, so far, there are few reports on the regulatory role of FAO and glycolysis in EndMT‐mediated diabetic renal fibrosis; so, there is still a long way to go for anti‐fibrotic drug treatment research. Here, ACTA1 is linked to diabetic kidney disease.