ACTA1 and renal fibrosis: In addition, the expression of FSP‐1 and α‐SMA in renal ECs of diabetic Sirt3 Tg + mice was significantly suppressed compared with diabetic controls, while the corresponding SIRT3 fl/fl mice exhibited higher expression levels of FSP‐1, α‐SMA and TGFβR1, suggesting that diabetic renal ECs are involved in renal fibrosis via EndMT.32