In addition, the expression of FSP‐1 and α‐SMA in renal ECs of diabetic Sirt3 Tg + mice was significantly suppressed compared with diabetic controls, while the corresponding SIRT3 fl/fl mice exhibited higher expression levels of FSP‐1, α‐SMA and TGFβR1, suggesting that diabetic renal ECs are involved in renal fibrosis via EndMT.32 This evidence concerns the gene SIRT3 and renal fibrosis.