FTO and obesity due to melanocortin 4 receptor deficiency: In the Brazilian admixed population, the FTO polymorphisms were associated with the development of obesity in adults (Ramos et al., 2012; Fonseca et al., 2020) and in children and youth (da Silva et al., 2013; Reuter et al., 2016), probably due to the high percentage of European ancestry in the studied samples.