ADRB3 and obesity due to melanocortin 4 receptor deficiency: Regarding the variants related to obesity, the risk allele (G) of the rs4994 variant (ADRB3) was found with slightly higher frequencies (average of 39.3%) in indigenous people than in continental populations (frequencies ranging from 8.2% in Europeans to 15.7% in Southeast Asians) and can be considered a good marker for association studies in indigenous.