For the six loci shared between depression and CAD (conjFDR<0.05), five (83%) of the lead SNPs had concordant direction of effect, 12 loci (86%) for TG, 6 loci (60%) for LDL, 6 loci (75%) for CRP which implies that CAD, higher TG, LDL and CRP increase the risk for depression. The gene discussed is CRP; the disease is major depressive disorder.