FASLG and diabetes mellitus: After glucose bolus challenge, SA-FasL Microgel subjects returned to normal blood glucose levels within 90 min, with comparable profiles to that of naïve animals before diabetes induction [area under the curve (AUC) analysis: pre-STZ (naïve) versus post-STZ (after STZ induction but before transplant), P < 0.0001; 3 months after transplant versus post-STZ, P < 0.0001; 6 months after transplant versus post-STZ, P = 0.0002] (Fig. 2C).