Furthermore, we found that Nras and Bcas2 both positively regulate epithelial proliferation and regeneration in vivo. Interestingly, Nras is widely expressed, and both Nras and Bcas2 have also been implicated in growth of epithelial tissue during carcinogenesis (32, 40), and Panx1 expression is associated with adverse outcomes in lung, renal and endometrial cancer (The Human Protein Atlas). This evidence concerns the gene NRAS and endometrial cancer.