VRK1 relates to poor prognosis of glioma by participating in the PI3K/AKT pathway (Ben et al., 2018); studies have also shown that ginsenoside Rg3 affects DNA damage and causes VRK1 upregulation and P53BP1 foci formation, thereby inhibiting lung cancer cell viability (Liu et al., 2019). Here, VRK1 is linked to glioma.