VRK1 and central nervous system cancer: VRK1 relates to poor prognosis of glioma by participating in the PI3K/AKT pathway (Ben et al., 2018); studies have also shown that ginsenoside Rg3 affects DNA damage and causes VRK1 upregulation and P53BP1 foci formation, thereby inhibiting lung cancer cell viability (Liu et al., 2019).