In CD4+ T cells of patients with lupus, upregulation of EZH2 and H3K27me3 alters the methylation status, and overexpression of EZH2 promotes CD4+ T cells adhesion to endothelial cells through demethylation and upregulation of JAM-A, thus increasing disease activity in lupus (Tsou et al., 2018). This evidence concerns the gene CD4 and systemic lupus erythematosus.