To further explore the mechanism of EZH2 regulating kidney injury in AKI, we find that EZH2 may mediate the transcription of E-cadherin, tissue inhibitor of metalloproteinase (TIMP)-2, tissue inhibitor of metalloproteinase (TIMP)-3 and Raf kinase inhibitor protein (RKIP) to regulate their expressions, thus destroying the adhesion and connection between cells and cells or cells and matrix, increasing apoptosis and inflammatory response (Zhou et al., 2018b; Ni et al., 2019). This evidence concerns the gene CDH1 and acute kidney injury.