In UUO mice models, Previous studies in our group find that PRMT1 and H4R3me2a are up-regulated in the UUO mice models, and inhibition of PRMT1 via AMI-1 can inhibit the activation of TGF-β/Smad3 signaling pathway and alleviate renal fibrosis (Zhu et al., 2020). The gene discussed is SMAD3; the disease is renal fibrosis.