Moreover, EZH2-mediated H3K27 methylation attenuates the expression of TIMP-2 and TIMP-3 by inducing promoter DNA methylation in prostate cancer (Shin and Kim, 2012) while the silencing of E-cadherin occurs through H3K27 methylation without DNA methylation in non-small-cell lung carcinoma (Jia et al., 2021). This evidence concerns the gene EZH2 and non-small cell lung carcinoma.