In vitro, BIX01294 has been shown to facilitates TRAIL-mediated apoptosis of human renal carcinoma Caki cells by downregulating survivin and upregulating DR5 expression, suggesting that BIX01294 could be a therapeutic strategy to overcome TRAIL resistance in cancer cells (Woo et al., 2018). Here, TNFSF10 is linked to renal carcinoma.