Previous studies of our research group (Zhou et al., 2018a; Ni et al., 2019) have proved that in mice models of AKI (including folic acid, IR and cisplatin-induced AKI models), EZH2 and its specific substrate H3K27me3 expressions are increased in the damaged kidney, blockade of EZH2 with 3-DZNeP (an inhibitor of S-adenosylhomocysteine hydrolase that inhibits the activity of EZH2) can reduce kidney injury and protect renal function. The gene discussed is EZH2; the disease is acute kidney injury.