On one hand, the pathogenesis of DN involves a variety of cell types, and various intracellular environment affects the gene regulation of EZH2 (Brasacchio et al., 2009); Secondly, in response to sustained injury, the role of EZH2-regulated signaling pathways changes, such as the EGFR signaling pathway, which is essential for the initial renal tubular cell repair response, but its continued activation will eventually lead to renal fibrosis (Tang et al., 2013); finally, the balance of antagonism between proteins also affects the expression of EZH2 (Wan et al., 2017). Here, EZH2 is linked to renal fibrosis.