EDN1 and renal fibrosis: Further studies in UUO and DN mice models show that Dot1L and HDAC2 counterbalance to regulate the gene transcription encoding endothelin 1 (Edn1) by modulating H3K79 di-methylation and H3 acetylation associated with the Edn1 promoter, and the loss of DOT1L promotes renal fibrosis by up-regulating ET1 (Zhang et al., 2020).