Our recent studies have shown that blockade of HDAC6 with ACY-1215 also attenuated renal fibrosis through a mechanism involving the inactivation of TGFβ1/Smad3, EGFR/AKT, STAT3 and NF-κB signaling pathways in a murine model of UUO injury (Chen et al., 2020). The gene discussed is SMAD3; the disease is renal fibrosis.