HDAC6 and acute kidney injury: In the past decade, several highly selective HDAC6 inhibitors have been developed, Tubastatin A (TA), has been found to be effective in improving polycystic kidney disease (ADPKD) (Cebotaru et al., 2016), hypertensive nephropathy (Choi et al., 2015), acute kidney injury (AKI) (Shi et al., 2017) and peritoneal fibrosis (Xu et al., 2017) in animal models.