JAK2 and Alzheimer disease: In another AD transgenic mouse model, baicalin inhibited Aβ-induced microglial activation and reduced Aβ-induced inflammatory cytokine (IL-6, TNF-α, and NO) secretion via the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway, thus providing a new means for the prevention and treatment of AD (Xiong et al., 2014).