Three potential compounds (Quercetin, Luteolin, Kaempferol), 10 core targets (CXCL10, CXCL8, ICAM1, IFNG, IL10, IL1B, IL2, IL4, IL6, TNF) and three key pathways (Cytokine−cytokine receptor interaction, Chagas disease, IL-17 signaling pathway) were identified based on the network pharmacology results. This evidence concerns the gene ICAM1 and Chagas disease.