In U251 and GBM primary cell lines, the evidence that IPA amplifies DNA damage before irradiation (Navarra et al., 2020), together with the finding of FBXW7 upregulation, here debated, are extremely intriguing since GBM therapeutic protocols include different combinations of ionizing radiation and TMZ, and the resistance is modulated by DNA repair systems (Stupp et al., 2005; Oldrini et al., 2020). Here, FBXW7 is linked to glioblastoma.