TNF and Alzheimer disease: However, several proinflammatory cytokines implicated in AD were significantly increased in adult female hippocampus by AIE after FDR correction for multiple comparisons including IFNα (11.5-fold, ****q < 0.0001), IL-6 (9-fold, ****q < 0.0001), IL-1β (7.5-fold, ****q < 0.0001), MCP-1 (6.7-fold, ****q < 0.0001), TNFα (3.7-fold, ***q < 0.001), and TLR4 (3-fold, ***q < 0.001, 2-way ANOVAs with Sidak’s post-test and FDR p-value correction).