A study by Hoffman et al. (2019) with voluntary drinking with lower BACs in adult 3xTg-AD mice showed increased staining of p-tau-199/202 in CA1 of the hippocampus and increased Aβ42/40 protein ratios in cortical brain regions 1 month after ethanol with no effects in wild type mice. This evidence concerns the gene MAPT and Alzheimer disease.