Given work that suggests proinflammatory signaling contributes to AD pathology (Zhang et al., 2013; Heneka et al., 2015; Jack et al., 2018; Dani et al., 2018; Long and Holtzman, 2019) and our finding that Aβ1–42 and p-tau-181 levels were strongly correlated with proinflammatory gene expression after AIE, we hypothesized that blocking proinflammatory signaling during ethanol would prevent AIE-exacerbation of AD pathology. This evidence concerns the gene MAPT and Alzheimer disease.