Specifically, the expression of HNRNPA2B1, KIAA1429 and ALKBH5 were lower in severe OSA patients than in normal controls, while YTHDF2, FMR1, IGF2BP1 and IGF2BP3 were upregulated (Figures 2A,B). This evidence concerns the gene IGF2BP3 and obstructive sleep apnea syndrome.