In addition, ZC3H13 and ALKBH5 were positively correlated in controls (with correlation R values of 0.53) but negatively correlated in severe OSA (with correlation R values of −0.63) (Figure 2D), implying that m6A regulators played a major role in the development of severe OSA. This evidence concerns the gene ZC3H13 and obstructive sleep apnea syndrome.