The 12 FRGs are divided into 4 categories according to their functions: lipid metabolism (GPX4, LPCAT3, ACSL5, ACSL6), antioxidant (CD44, SESN2, AIFM2), iron metabolism (CISD1, HSPB1), and cancer metabolism (SOCS1, FH, G3BP1). This evidence concerns the gene SESN2 and cancer.