We found that H19 was downregulated in both atopic dermatitis (Fold Change FC =0.31; FDR = 3.26x10−6) and psoriasis (Fold Change FC = 0.05; FDR = 3.34x10−15) lesional skin, and it was also depleted in the IFN and IL17/TNF stimulated keratinocytes, further supporting our understanding of aberrant differentiation of keratinocytes in many skin diseases, such as psoriasis and atopic dermatitis (Li et al., 2017; Tang et al., 2020). Here, TNF is linked to atopic eczema.