Moreover, though with a lesser degree than that in lesional skin, SPRR2C is significantly upregulated in both the non-lesional skin of psoriasis and atopic dermatitis (Figure 1A), and it is also induced through IL17 and IL17 + TNF stimulation in keratinocytes; while the dysregulation of UCA1 was also observed in the lesional skin but not the non-lesional skin of AD and psoriasis. The gene discussed is TNF; the disease is psoriasis.