We highlighted the different skin-expressing lncRNAs, including H19, which is significantly down-regulated in lesional skin of AD/psoriasis and upon cytokine stimulation in keratinocytes; it is also negatively correlated with CYP1A1 (r = -0.75, p = 8 × 10−73), a gene involved in drug metabolism and skin barrier homeostasis, in keratinocytes. This evidence concerns the gene CYP1A1 and psoriasis.