As for PCa, a few studies reported that TK1 can be used as a diagnostic biomarker through bioinformatic analysis and serological TK1 may be a potential proliferating biomarker for early detection (Li et al., 2018; Wang et al., 2018; Jagarlamudi et al., 2019; Song et al., 2019; Wang et al., 2020). This evidence concerns the gene TK1 and posterior cortical atrophy.