Combined RankProd with genetic algorithm optimized artificial neural network (GA-ANN), Hou et al. identified a 15-gene signature that exhibited a great capacity for diagnosis and prognosis of PCa and found that C1QTNF3 was a good predictor for PCa diagnosis (Hou et al., 2018). The gene discussed is C1QTNF3; the disease is posterior cortical atrophy.