WWOX and coronary artery disorder: This study investigated the genotypes of SNPs (rs2710642, rs10496099, rs3132584, rs3130685, rs2222896, and rs2278075) in EHBP1, TUBB, and WWOX in the Guangxi Han population and analyzed the relationship between SNPs, gene-gene (G × G) and gene-environment (G × E) interactions, and the risk of CAD and IS, to explore the possible pathogenic mechanism of these genes and provides a theoretical basis for early CAD or IS prevention and treatment.