For example, circCNTNAP3 inhibits proliferation and promotes apoptosis in p53 wild-type esophageal squamous cell carcinoma (ESCC) cells; mechanistically, circCNTNAP3 promotes the expression of p53 by sponging miR-513a-5p (Wang H. et al., 2020). Here, TP53 is linked to esophageal squamous cell carcinoma.