Yeo et al. found that downregulating the autophagy regulator FIP200 in mouse breast cancer models impaired STAT3 or TGFβ/Smad pathway, respectively, and diminished the tumor-initiating properties of both ALDH+ and CD29hiCD61 + breast cancer stem cells, thereby limiting tumor growth and reducing the number of breast cancer stem cells (Yeo et al., 2016). The gene discussed is RB1CC1; the disease is breast carcinoma.