The results showed that LC3 expression was more in the high thickness group (>6 mm), which was significantly different from SCC in the moderate thickness group (2.1–6 mm) and the mild thickness group (<2 mm), This study suggested that high LC3 expression could be used as a marker of tumor invasive ability in SCC tissue (Sivridis et al., 2011). Here, MAP1LC3A is linked to neoplasm.